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PRECISION REGENERATIVE MEDICINE
We are interested in understanding how cells build and remodel their environments in physiology and disease. Our team is pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights by precisely directing donor cells and modulating the host response to treat tissue injury, degeneration and fibrosis. Target organs include the bone marrow, bones, and lungs.
We are interested in understanding how cells build and remodel their environments in physiology and disease. Our team is pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights by precisely directing donor cells and modulating the host response to treat tissue injury, degeneration and fibrosis. Target organs include the bone marrow, bones, and lungs.
Research areas
Niche design for single cells
We are combining biomaterial design with microtechnologies to build instructive niches that can precisely guide single cells to regenerate tissues.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
We are combining biomaterial design with microtechnologies to build instructive niches that can precisely guide single cells to regenerate tissues.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
Engineering host remodeling
We are developing instructive materials to control how cells remodel host tissues after damage.
Wong et al. Inhibition of aberrant tissue remodeling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues. Nat. Biomed. Eng. 2022.
Wong et al. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
We are developing instructive materials to control how cells remodel host tissues after damage.
Wong et al. Inhibition of aberrant tissue remodeling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues. Nat. Biomed. Eng. 2022.
Wong et al. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
Extracellular nanostructures in context
We are leveraging engineered biomaterials to investigate how extracellular nanostructures with regenerative functions are secreted from cells and transported in tissues.
Lenzini et al. Cell-matrix interactions regulate functional extracellular vesicle secretion from mesenchymal stromal cells. ACS Nano. 2021.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
We are leveraging engineered biomaterials to investigate how extracellular nanostructures with regenerative functions are secreted from cells and transported in tissues.
Lenzini et al. Cell-matrix interactions regulate functional extracellular vesicle secretion from mesenchymal stromal cells. ACS Nano. 2021.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
Institution
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Funding
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