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PRECISION REGENERATIVE MEDICINE
We are interested in understanding how cells build and remodel their environments in physiology and disease. Our team is pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights by precisely directing donor cells and modulating the host response to treat tissue injury, degeneration and fibrosis. Target organs include the bone marrow, bones, and lungs.
We are interested in understanding how cells build and remodel their environments in physiology and disease. Our team is pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights by precisely directing donor cells and modulating the host response to treat tissue injury, degeneration and fibrosis. Target organs include the bone marrow, bones, and lungs.
Research areas
Biomaterial design for single cell mechanobiology and encapsulation therapy
We are combining biomaterial design with microtechnologies to precisely control matrix properties at the single cell level and to advance the field of single cell mechanobiology and encapsulation therapy.
Wong et al. Inhibition of aberrant tissue remodeling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues. Nat. Biomed. Eng. 2021.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
We are combining biomaterial design with microtechnologies to precisely control matrix properties at the single cell level and to advance the field of single cell mechanobiology and encapsulation therapy.
Wong et al. Inhibition of aberrant tissue remodeling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues. Nat. Biomed. Eng. 2021.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
Physical regulation of stromal cells in immunity and immunotherapy
We are leveraging designer hydrogels to understand how matrix biophysical cues impact the ability of stromal cells to regulate immune cells and using these insights to improve immunomodulatory therapies.
Wong et al. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
We are leveraging designer hydrogels to understand how matrix biophysical cues impact the ability of stromal cells to regulate immune cells and using these insights to improve immunomodulatory therapies.
Wong et al. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
Extracellular vesicles in matrices
We are studying how extracellular vesicles are produced from cells in matrices and transport through matrices. We are using these insights to improve extracellular vesicle-based therapeutics.
Lenzini et al. Cell-matrix interactions regulate functional extracellular vesicle secretion from mesenchymal stromal cells. ACS Nano. 2021.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
We are studying how extracellular vesicles are produced from cells in matrices and transport through matrices. We are using these insights to improve extracellular vesicle-based therapeutics.
Lenzini et al. Cell-matrix interactions regulate functional extracellular vesicle secretion from mesenchymal stromal cells. ACS Nano. 2021.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
Institution
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Funding
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