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PRECISION REGENERATIVE MEDICINE
We are pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights for restoration of tissue functions by precisely directing donor cells and modulating the host response.
We are pursuing multidisciplinary approaches to understand fundamentals in physical biology of regenerative processes and to leverage these insights for restoration of tissue functions by precisely directing donor cells and modulating the host response.
Research areas
Biomaterial design for single cell mechanobiology
We are combining biomaterial design with microtechnologies to precisely control matrix properties at the single cell level and to advance the field of single cell mechanobiology.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
We are combining biomaterial design with microtechnologies to precisely control matrix properties at the single cell level and to advance the field of single cell mechanobiology.
Wong et al. Controlled deposition of 3D matrices to direct single cell functions. Adv. Sci. 2020; 2001066.
Devine et al. Hydrogel micropost arrays with single post tunability to study cell volume and mechanotransduciton. Adv. Biosyst. 2020: 2000012.
Physical regulation of stromal cells in immunity
We are leveraging designer hydrogels to understand how matrix biophysical cues impact the ability of stromal cells to regulate immune cells and using these insights to improve cell-based therapeutics.
Wong et al. Soft extacellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
We are leveraging designer hydrogels to understand how matrix biophysical cues impact the ability of stromal cells to regulate immune cells and using these insights to improve cell-based therapeutics.
Wong et al. Soft extacellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci. Adv. 2020; 6:eaaw0158
Extracellular vesicles in matrix
We are studying how extracellular vesicles transport through matrices and using these insights to improve extracellular vesicle-based therapeutics.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
We are studying how extracellular vesicles transport through matrices and using these insights to improve extracellular vesicle-based therapeutics.
Lenzini et al. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nano. 2020; 15: 217-223.
Institution
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Funding
